Zika Virus Infection

(Content revised 02/2024)

Causative agent

Zika virus infection is a mosquito-borne disease caused by Zika virus.

Clinical features

Most people infected with Zika virus infection are asymptomatic. For patients with symptoms, they commonly present with rash, fever, conjunctivitis, muscle and joint pain, malaise and headache. These symptoms are generally mild and usually last for 2 – 7 days.

Zika virus infection during pregnancy is a cause of microcephaly and other congenital malformations in the infant. Congenital malformations can occur following both symptomatic and asymptomatic infection. Zika infection in pregnancy can also cause complications such as fetal loss, stillbirth and preterm birth.

Zika virus infection can also cause Guillain-Barré syndrome, neuropathy and myelitis.

Mode of transmission

Zika virus is primarily transmitted to humans through the bite of an infected Aedes mosquito. Aedes aegypti, which is currently not found in Hong Kong, is considered the most important vector. Other Aedes mosquito species such as Aedes albopictus, which is commonly found in Hong Kong, are also potential vectors.

Zika virus can also be transmitted from mother to fetus during pregnancy, as well as through sexual contact, transfusion of blood and blood products, and possibly through organ transplantation.

Incubation period

The incubation period of Zika virus infection ranges from 3 – 14 days.

Management

There is no specific treatment for Zika virus infection. Symptomatic relief and prevention of dehydration is the mainstay of treatment. If symptoms worsen, patients should seek medical care and advice.

Prevention

AAt present, there is no vaccine available against Zika virus infection. The best preventive measure is to avoid mosquito bites and prevent mosquito proliferation. The public is also advised to take precautions to prevent sexual transmission of Zika virus.

Beware of Zika Virus Infection

Special notes for pregnant women and women preparing for pregnancy

  • Pregnant women should pay close attention to the infection risk if they travel to areas with active transmission*.
  • If going to areas of active Zika virus transmission, women planning to conceive or their male sexual partners, arrange a consultation with a doctor at least 6 weeks before the trip, and have extra preventive measures to avoid mosquito bite
  • Pregnant women are advised to use DEET-containing insect repellent during travel to areas with active transmission.
  • Sexual partners of pregnant women living in or returning from areas of active transmission should practice safer sex or abstain from sexual activity throughout pregnancy.
  • Pregnant women returning from areas with active transmission are advised to:
    • Attend antenatal follow up regularly and inform the attending doctor about recent travel history;
    • Observe for symptoms of Zika virus infection and seek medical advice as soon as possible if feeling unwell;
    • Apply insect repellant for at least 21 days after arrival in Hong Kong.

Prevention of sexual transmission#

  • All travellers should practice safer sex (including correct and consistent use of condoms) or abstain from sexual activity during travel to areas of active transmission.
  • Male and female travellers returning from areas of active transmission should practice safer sex or abstinence for at least 3 months and 2 months respectively upon return.

* Please refer to CHP website for most updated information on Zika Virus Infection.